Research Details

  • Research Name : TRACT
  • Client : Mbale Clinical Research Institute
  • Category : Clinical and Biomedical Research
  • Research Year : April, 2019
  • Location : Uganda
  • Delivery Mode : Research

The Transfusion and Treatment of severe Anaemia in African Children

The Transfusion and Treatment of severe Anaemia in African Children (TRACT) is a randomised controlled Trial. TRACT is evaluating three different ways to reduce short and longer-term mortality and morbidity following admission to hospital with severe anaemia in African children.

TRACT will therefore compare three different ways that outcomes could be improved:

  • Liberal transfusion (30ml/kg whole blood) versus conservative transfusion (20ml/kg) versus no transfusion (control). The control is only for children with uncomplicated severe anaemia (haemoglobin 4-6 g/dl);
  • Post-discharge multi-vitamin multi-mineral supplementation (including folate and iron) versus routine care (folate and iron) for 3 months;
  • post-discharge cotrimoxazole prophylaxis for 3 months versus no prophylaxis.