Publications

Since the beginning of Mbale Clinical Research Institute, the institute has produced several publications under the various studies which include:

FEAST STUDY

Publications:

• Mortality after fluid bolus in African children with severe infections.

  K Maitland, S Kiguli, RO Opoka, C Engoru, >P Olupot-Olupot, SO Akech, … New England Journal of Medicine 364 (26), 2483-2495
• Exploring mechanisms of excess mortality with early fluid resuscitation: insightsfrom the FEAST trial

  K Maitland, EC George, JA Evans, S Kiguli, P Olupot-Olupot, SO Akech, … BMC medicine 11 (1), 68
• Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness

  S Kiguli, K Maitland, EC George, P Olupot-Olupot, RO Opoka, C Engoru, … BMC medicine 13 (1), 21
• ‘The words will pass with the blowing wind’: staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals

  S Molyneux, M Njue, M Boga, L Akello, P Olupot-Olupot, C Engoru, … PloS one 8 (2), e54894
• Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) score

  EC George, AS Walker, S Kiguli, P Olupot-Olupot, RO Opoka, C Engoru, … BMC medicine 13 (1), 174
• WHO guidelines on fluid resuscitation in children: missing the FEAST data

  S Kiguli, SO Akech, G Mtove, RO Opoka, C Engoru, P Olupot-Olupot, … Bmj 348, f7003
• Management of severe malaria: Results from recent trials

  P Olupot-Olupot, K Maitland Hot Topics in Infection and Immunity in Children IX, 241-250
• Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa

  A Aramburo, J Todd, EC George, S Kiguli, P Olupot-Olupot, RO Opoka, … BMC medicine 16 (1), 37
• FEAST Trial Group: Mortality after fluid bolus in African children with shock

  K Maitland, S Kiguli, R Opoka, C Engoru, P Olupot-Olupot, S Akech, … N Engl J Med 364, 2483-2495
• Mortality risk over time after early fluid resuscitation in African children

  E George, S Kiguli, P Olupot Olupot, R Opoka, C Engoru, S Akech, … Critical Care
• WHO GUIDELINES ON FLUID RESUSCITATION IN CHILDREN Concerns about intravenous fluids given to critically ill children Reply

  S Kiguli, SO Akech, G Mtove, RO Opoka, C Engoru, P Olupot-Olupot, … BMJ-BRITISH MEDICAL JOURNAL 348 (ARTN g16)
• Ken Ong and Ze’ev Hochberg

  K Maitland, S Kiguli, RO Opoka, C Engoru, P Olupot-Olupot, SO Akech, … Yearbook of Pediatric Endocrinology 2012: Endorsed by the European Society …
• Fluid Expansion as Supportive Therapy (FEAST) trial: mortality after fluid bolus in African children

  P Olupot-Olupot Tropical Medicine & International Health 17

TRACT STUDY

• Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

  A Mpoya, S Kiguli, P Olupot-Olupot, RO Opoka, C Engoru, M Mallewa, … Trials 16 (1), 593
• Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub‐Saharan Africa

  S Uyoga, A Mpoya, P Olupot‐Olupot, S Kiguli, RO Opoka, C Engoru, … Vox sanguinis 114 (4), 340-348
• Immediate transfusion in African children with uncomplicated severe anemia

  K Maitland, S Kiguli, P Olupot-Olupot, C Engoru, M Mallewa, … New England Journal of Medicine 381 (5), 407-419
• Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial

  K Maitland, P Olupot-Olupot, S Kiguli, G Chagaluka, F Alaroker, … The Lancet Global Health 7 (10), e1435-e1447
• Authors’ reply to Southall

  S Kiguli, SO Akech, G Mtove, RO Opoka, C Engoru, P Olupot-Olupot, … Bmj 348, g1619
• Cotrimoxazole or multi-mineral multi-vitamins to improve post-discharge outcomes following severe anaemia in African children: a randomised controlled trial

  K Maitland, P Olupot-Olupot, S Kiguli, G Chagaluka, F Alaroker, … Lancet Global Health 7 (10)
• Transfusion timing and volume in African children with severe Anemia.

  K Maitland, P Olupot-Olupot, S Walker Massachusetts Medical Society
• Abstract O-57: LACTATE CLEARANCE AS A PROGNOSTIC MARKER OF MORTALITY IN SEVERELY ILL FEBRILE CHILDREN IN EAST AFRICA

  A Aramburo, J Todd, EC George, S Kiguli, P Olupot-Olupot, RO Opoka, … Pediatric Critical Care Medicine 19 (6S), 24.

SEVERE MALARIA

• High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in Eastern Uganda

  Peter Olupot-Olupot, Charles Engoru, Sophie Uyoga, Rita Muhindo, Alex Macharia, Sarah Kiguli, Robert O Opoka, Samuel Akech, Carolyne Ndila, Richard Nyeko, George Mtove, Julius Nteziyaremye, Martin Chebet, Elizabeth C George, Abdel G Babiker, Diana M Gibb, Thomas N Williams, Kathryn Maitland
• Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children.

  Kotlyar S, Nteziyaremye J, Olupot-Olupot P, Akech SO, Moore CL, Maitland K.

  Trans R Soc Trop Med Hyg. 2014 May;108(5):283-9. doi: 10.1093/trstmh/tru040. Epub 2014 Mar 16.
• Inhibition of an erythrocyte tyrosine kinase with imatinib prevents Plasmodium falciparum egress and terminates parasitemia

  Kristina R Kesely, Antonella Pantaleo, Francesco M Turrini, Peter Olupot-Olupot, Philip S Low
• Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury

  James A Church, Lydia Nyamako, Peter Olupot-Olupot, Kathryn Maitland, Britta C Urban
• Assessment of myocardial function and injury by echocardiography and cardiac biomarkers in African children with severe Plasmodium falciparum malaria

  Simon Kotlyar, Peter Olupot-Olupot, Julius Nteziyaremye, Samuel O Akech, Sophie Uyoga, Rita Muhindo, Christopher L Moore, Kathryn Maitland
• Neonatal and congenital malaria: a case series in malaria endemic eastern Uganda

  Peter Olupot-Olupot, Emma IE Eregu, Ketty Naizuli, Julie Ikiror, Linda Acom, Kathy Burgoine
• Asymptomatic plasmodium parasites among adults in eastern uganda: a case of donor blood screening at mbale regional blood bank

  Simon Peter Inyimai, Mosses Ocan, Benjamin Wabwire, Peter Olupot-Olupot
• The Burden and Spectrum of Paediatric Severe Malaria and Aetiology of Dark Urine Syndrome in Eastern Uganda

  Peter Olupot-Olupot

NEONATOLOGY

• Staged implementation of a two-tiered hospital-based neonatal care package in a resource-limited setting in Eastern Uganda

  Kathy Burgoine, Juliet Ikiror, Sylivia Akol, Margaret Kakai, Sara Talyewoya, Alex Sande, Tom Otim, Francis Okello, Adam Hewitt-Smith, Peter Olupot-Olupot
• Preventing neonatal sepsis in rural Uganda: a cross-over study comparing the tolerance and acceptability of three alcohol-based hand rub formulations

  James Ditai, M Mudoola, M Gladstone, J Abeso, John Dusabe-Richards, M Adengo, Peter Olupot-Olupot, ED Carrol, J Storr, A Medina-Lara, Brian Faragher, AD Weeks
• Reducing preterm mortality in eastern Uganda: the impact of introducing low-cost bubble CPAP on neonates< 1500 g

  F Okello, E Egiru, J Ikiror, L Acom, KSM Loe, P Olupot-Olupot, K Burgoine
• BabyGel pilot: a pilot cluster randomised trial of the provision of alcohol handgel to postpartum mothers to prevent neonatal and young infant infection-related morbidity in …

  J Ditai, J Abeso, NM Odeke, N Mobbs, John Dusabe-Richards, M Mudoola, ED Carrol, P Olupot-Olupot, J Storr, A Medina-Lara, M Gladstone, EB Faragher, AD Weeks
• In search of a primary outcome for community-based newborn infection trials in Eastern Uganda: a nested cohort study within the BabyGel pilot trial

  NA Mobbs, James Ditai, J Abeso, EB Faragher, ED Carrol, M Gladstone, A Medina-Lara, Peter Olupot-Olupot, AD Weeks
• Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol

  Kathy Burgoine, Emma Egiru, Juliet Ikiror, Linda Acom, Sylivia Akol, Peter Olupot-Olupot

HIV STUDY

• Was the “ABC” approach (abstinence, being faithful, using condoms) responsible for Uganda’s decline in HIV?

  Elaine M Murphy, Margaret E Greene, Alexandra Mihailovic, Peter Olupot-Olupot
• Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda

  Andrew Kiboneka, Jonathan Wangisi, Christine Nabiryo, Juliet Tembe, Sylvia Kusemererwa, Peter Olupot-Olupot, Michel Joffres, Aranka Anema, Curtis L Cooper, Julio S Montaner, Edward J Mills
• Adherence to antiretroviral therapy among a conflict-affected population in Northeastern Uganda: a qualitative study

  Peter Olupot-Olupot, Andrew Katawera, Curtis Cooper, Will Small, Aranka Anema, Edward Mills
• Orphanhood predicts delayed access to care in Ugandan children

  Henry Ntanda, Peter Olupot-Olupot, Peter Mugyenyi, Cissy Kityo, Rebecca Lowes, Curtis Cooper, Viviane Lima, Edward Mills
• Pediatric HIV therapy in armed conflict

  Andrew Kiboneka, Ricky J Nyatia, Christine Nabiryo, Peter Olupot-Olupot, Aranka Anema, Curtis Cooper, Edward Mills
• Where have all the children gone? High HIV prevalence in infants attending nutrition and inpatient entry points

  Charles Kiyaga, Brittany Urick, Youyi Fong, Christopher Okiira, Nicolette Nabukeera‐Barungi, Denis Nansera, Emmanuel Ochola, Julius Nteziyaremye, Victor Bigira, Isaac Ssewanyana, Peter Olupot‐Olupot, Trevor Peter, Anisa Ghadrshenas, Lara Vojnov
• Rapid Serological Tests Ineffectively Screen for HIV Exposure in HIV-Positive Infants.

  Brittany Urick, Youyi Fong, Christopher Okiira, Nicolette Nabukeera-Barungi, Denis Nansera, Emmanuel Ochola, Julius Nteziyaremye, Victor Bigira, Isaac Ssewanyana, Peter Olupot-Olupot, Trevor Peter, Anisa Ghadrshenas, Lara Vojnov, Charles Kiyaga
• Patient retention on antiretroviral therapy programme: risk factor analysis of a Uganda cohort

  EJ Mills, P Olupot-Olupot, C Cooper, J Meadway, H Boorman, A Das, JSO Obbo
• Evaluation of antiretroviral therapy information system in Mbale Regional Referral Hospital, Uganda

  Peter Olupot-Olupot
• A study using knowledge, attitude and practices on the prevention of HIV-1 vertical transmission with outcomes in early infant HIV-1 diagnosis in Eastern Uganda

  Sydney Nsubuga, Jeanette Meadway, Peter Olupot-Olupot
• Where have all the children gone? High HIV prevalence in infants attending nutrition and inpatient entry points

  Brittany Urick, Youyi Fong, Christopher Okiira, Nicolette Nabukeera-Barungi, Denis Nansera, Emmanuel Ochola, Julius Nteziyaremye, Victor Bigira, Isaac Ssewanyana, Peter Olupot-Olupot, Peter Trevor, Anisa Ghadrshenas, Lara Vojnov
• Trends and practices in early infant diagnosis of HIV infection

  P Olupot-Olupot, S Nsubuga, J Meadway
• Overcoming challenges to establishing a post-exposure prophylaxis service in a centre in Eastern Uganda

  E Fomum, S Obbo, J Meadway, P Olupot-Olupot
• HiV-Link: A mobile phone-based expert consultation platform for HIV/AIDS care in Ethiopia and Uganda

  M Nelson, Z Temesgen, P Olupot-Olupot, W Warren, G Robertson, D Mansuri, C Samuel
• In Eastern Uganda training in post-exposure prophylaxis (PEP) after occupational exposure to HIV produced significant improvements in practice and improved links between HIV …

  J Obbo, P Olupot-Olupot, J Balyejjusa, J Meadway

REACH STUDY

• Hydroxyurea therapy for children with sickle cell anemia in sub‐saharan africa: rationale and design of the REACH trial

  Patrick T McGann, Léon Tshilolo, Brigida Santos, George A Tomlinson, Susan Stuber, Teresa Latham, Banu Aygun, Stephen K Obaro, Peter Olupot‐Olupot, Thomas N Williams, Isaac Odame, Russell E Ware, Reach Investigators
• Hydroxyurea for children with sickle cell anemia in sub-Saharan Africa

  Léon Tshilolo, George Tomlinson, Thomas N Williams, Brígida Santos, Peter Olupot-Olupot, Adam Lane, Banu Aygun, Susan E Stuber, Teresa S Latham, Patrick T McGann, Russell E Ware
• Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub‐Saharan Africa

  Patrick T McGann, Thomas N Williams, Peter Olupot‐Olupot, George A Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Santos, Léon Tshilolo, Russell E Ware, REACH Investigators
• Realizing effectiveness across continents with hydroxyurea (REACH): A prospective multi-national trial of hydroxyurea for sickle cell anemia in sub-Saharan Africa

  Leon Tshilolo, George Tomlinson, Thomas N Williams, Brigida Santos, Peter Olupot-Olupot, Adam Lane, Banu Aygun, Susan Stuber, Teresa Latham, Patrick T McGann, Russell E Ware
• Splenomegaly in Children with Sickle Cell Anemia Receiving Hydroxyurea in Sub-Saharan Africa

  Leon Tshilolo, George A Tomlinson, Patrick T McGann, Teresa S Latham, Peter Olupot-Olupot, Brigida Santos, Banu Aygun, Susan Stuber, Adam Lane, Thomas N Williams, Russell E Ware
• Effects of Hydroxyurea Treatment on Malaria Infections in Sub-Saharan Africa

  Peter Olupot-Olupot, George A Tomlinson, Teresa S Latham, Patrick T McGann, Brigida Santos, Banu Aygun, Susan Stuber, Leon Tshilolo, Adam Lane, Thomas N Williams, Russell E Ware
• Realizing Effectiveness Across Continents with Hydroxyurea (REACH): Enrollment and Baseline Characteristics

  Patrick McGann, Peter Olupot-Olupot, Leo Tshilolo, Thomas Williams, Brigida Santos, Jose Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Teresa Latham, Banu Aygun, Stephen Obaro, George Tomlinson, Russell Ware

DIARRHOEA

• Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

  Kirsty A Houston, Jack Gibb, Peter Olupot-Olupot, Nchafatso Obonyo, Ayub Mpoya, Margaret Nakuya, Rita Muhindo, Sophie Uyoga, Jennifer A Evans, Roisin Connon, Diana M Gibb, Elizabeth C George, Kathryn Maitland
• G265 (P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis

  K Houston, J Gibb, A Mpoya, N Obonyo, P Olupot-Olupot, E George, D Gibb, K Maitland
• dehydration: WHO plan C versus slower rehydration

  Kirsty A Houston, Jack G Gibb, Ayub Mpoya, Nchafatso Obonyo, Peter Olupot-Olupot, Margeret Nakuya, Jennifer A Evans, Elizabeth C George, Diana M Gibb, Kathryn Maitland
• Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration

  Kirsty A Houston, Jack G Gibb, Ayub Mpoya, Nchafatso Obonyo, Peter Olupot-Olupot, Margeret Nakuya, Jennifer A Evans, Elizabeth C George, Diana M Gibb, Kathryn Maitland

INFECTIOUS DISEASE

• Chronic viral hepatitis may diminish the gains of HIV antiretroviral therapy in sub-Saharan Africa

  Curtis L Cooper, Edward Mills, Ben O Wabwire, Nathan Ford, Peter Olupot-Olupot
• Ebola in children: epidemiology, clinical features, diagnosis and outcomes

  Peter Olupot-Olupot

MALNUTRITION

• Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)

  Nchafatso Obonyo, Bernadette Brent, Peter Olupot-Olupot, Michael Boele van Hensbroek, Irene Kuipers, Sidney Wong, Kenji Shiino, Jonathan Chan, John Fraser, Job BM van Woensel, Kathryn Maitland
• Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment

  Helen Nightingale, Kevin J Walsh, Peter Olupot-Olupot, Charles Engoru, Tonny Ssenyondo, Julius Nteziyaremye, Denis Amorut, Margaret Nakuya, Margaret Arimi, Gary Frost, Kathryn Maitland
• Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial

  Kevin Walsh, Nuala Calder, Peter Olupot-Olupot, Tonny Ssenyondo, William Okiror, Charles Bernard Okalebo, Rita Muhindo, Ayub Mpoya, Elaine Holmes, Julian Marchesi

DIAGNOSTICS

• Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

  Peter Olupot-Olupot, Natalie Prevatt, Charles Engoru, Julius Nteziyaremye, Denis Amorut, Martin Chebet, Tonny Senyondo, Paul Ongodia, Carolyne M Ndila, Thomas N Williams, Kathryn Maitland
• Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited Setting

  Kathy Burgoine, Juliet Ikiror, Ketty Naizuli, Linda Achom, Sylivia Akol, Peter Olupot-Olupot

TUBERCULOSIS(TB)

• Multi-drug resistant TB (MDR-TB) and HIV: patient characteristics and outcomes in resources limited settings

  J Meadway, D Waiswa, S Obbo, P Olupot-Olupot
• Multidrug resistant tuberculosis (MDR-TB) in emerging economies in Sub-Saharan Africa: clinicians’ public health concerns

  Peter Olupot-Olupot, Damalie Namuyodi, Jeanette Meadway
• Multi-drug resistant TB (MDR-TB) and HIV; the effect of introducing molecular testing for MDR-TB at a regional centre in Uganda: P400

  D Namuyodi, J Meadway, P Olupot-Olupot

INJURY SURVEILLANCE STUDY

• Health implications of small arms and light weapons in eastern Uganda

  Andrew D Pinto, Peter Olupot-Olupot, Victor R Neufeld
• Implementing a hospital based injury surveillance system in Africa: lessons learned

  Diego E Zavala, Simon Bokongo, Ime A John, Ismail Mpanga Senoga, Robert E Mtonga, Aminu Z Mohammed, Walter Odhiambo Anjango, Peter Olupot-Olupot

COAST STUDY

• Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

  Kathryn Maitland, Sarah Kiguli, Robert O Opoka, Peter Olupot-Olupot, Charles Engoru, Patricia Njuguna, Victor Bandika, Ayub Mpoya, Andrew Bush, Thomas N Williams, Richard Grieve, Zia Sadique, John Fraser, David Harrison, Kathy Rowan

AMR

• Bacterial aetiology and antibiotic susceptibility profile of post operative sepsis among surgical patients in a tertiary hospital in rural Eastern Uganda

  George Masifa, Jacob Stanley Iramiot, Rita Muhindo, Peter Olupot-Olupot, Ann Nanteza

SICKLE CELL DISEASE

• The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study

  Amina Nardo-Marino, Thomas N Williams, Peter Olupot-Olupot

ACUTE PAEDIATRICS

• Perspectives on aetiology, pathophysiology and management of shock in African children

  Julius Nteziyaremye, George Paasi, Kathy Burgoine, Jaffer Sadiq Balyejjusa, Crispus Tegu, Peter Olupot-Olupot

ETHICS

• Optimising informed consent for participants in a randomised controlled trial in rural Uganda: a comparative prospective cohort mixed-methods study

  James Ditai, J Kanyago, MR Nambozo, NM Odeke, J Abeso, John Dusabe-Richards, Peter Olupot-Olupot, ED Carrol, A Medina-Lara, M Gladstone, J Storr, Brian Faragher, AD Weeks
• Optimising informed consent for participants in randomised controlled trials: A comparison of three different methods: EP6. 046

  J Ditai, J Abeso, M Mudoola, B Faragher, M Adengo, J Richards, E Carrol, P Olupot-Olupot, J Storr, M Gladstone, A Medina-Lara, A Weeks

COMMUNITY SURVEY

• Prevalence of Anemia and Associated Risk Factors among Children in Northwestern

  Legason Ismail, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot, Banson Barugahare
• Prevalence of anaemia and associated risk factors among children in North-western Uganda: a cross sectional study

  Ismail Dragon Legason, Alex Atiku, Ronald Ssenyonga, Peter Olupot-Olupot, John Banson Barugahare

TRAINING

• Educational curricula and programs in adolescent medicine for health workers in low-and middle-income countries: A scoping review

  Kathleen K Miller, Sarah Jane Brown, Betsy Pfeffer, Peter Olupot-Olupot, Sabrina Kitaka
• Capacity building for senior clinicians improves health care in a resource-poor setting

  P Olupot-Olupot, J Meadway

HBX

• Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

  Peter Olupot-Olupot, Charles Engoru, Jennifer Thompson, Julius Nteziyaremye, Martin Chebet, Tonny Ssenyondo, Cornelius M Dambisya, Vicent Okuuny, Ronald Wokulira, Denis Amorut, Paul Ongodia, Ayub Mpoya, Thomas N Williams, Sophie Uyoga, Alex Macharia, Diana M Gibb, A Sarah Walker, Kathryn Maitland

EDX

• Endotoxaemia is common in children with Plasmodium falciparum malaria

  Peter Olupot-Olupot, Britta C Urban, Julie Jemutai, Julius Nteziyaremye, Harry M Fanjo, Henry Karanja, Japhet Karisa, Paul Ongodia, Patrick Bwonyo, Evelyn N Gitau, Alison Talbert, Samuel Akech, Kathryn Maitland

OXYGEN STUDY

• Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative study

  Jonathan W Dauncey, Peter Olupot-Olupot, Kathryn Maitland